Article
Adenoviral gene transfer of beta3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma.
The American journal of pathology - 1 Nov 1998
Hsu M Y, Shih D T, Meier F E, Van Belle P, Hsu J Y, Elder D E, Buck C A, Herlyn M
Abstract excerpt
Expression of the beta3 subunit of the alphavbeta3 vitronectin receptor on melanoma cells is associated with tumor thickness and the ability to invade and metastasize. To address the role of alphavbeta3 in the complex process of progression from the nontumorigenic radial to the tumorigenic vertic...
Topics
- Adenoviridae
- Animals
- Antigens, CD
- Apoptosis
- Cell Transformation, Neoplastic
- Female
- Gene Expression Regulation, Neoplastic
- Gene Transfer Techniques
- Humans
- Integrin beta3
- Melanoma
- Mice
- Mice, SCID
- Neoplasm Invasiveness
- Phenotype