Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo.

doi:10.1038/sj.onc.1202148

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Article

Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo.

Oncogene - 29 Oct 1998

Deng J, Xia W, Hung M C

Abstract excerpt

Disruption of apoptotic pathways is a major factor in the multistep process of tumorigenesis, whereas induction of apoptosis can be important for tumor suppression and cancer therapy. The adenovirus type 5 E1A gene provides a useful tool to study the function of tumor suppression and apoptosis. E...

Topics

Adenovirus E1A Proteins
Animals
Antineoplastic Agents
Apoptosis
Cell Adhesion
Cell Division
Cell Survival
Cisplatin
Culture Media, Serum-Free
DNA Fragmentation
DNA, Neoplasm
Female
Genes, Tumor Suppressor
Genes, Viral
Melanoma, Experimental
Mice
Mice, Inbred BALB C
Mice, Inbred C3H

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