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Article

The α6β4 Integrin Maintains the Survival of Human Breast Carcinoma Cells <i>In vivo</i>

1 Dec 2005

Abstract excerpt

The alpha6beta4 integrin has been widely implicated in carcinoma function in vitro; however, in vivo data are scarce. To determine the importance of alpha6beta4 in tumor progression, a SUM-159 breast carcinoma cell line that is essentially devoid of alpha6beta4 expression was generated using an RNA interference strategy. Loss of alpha6beta4 expression inhibits colony formation in soft agar assays, suggesting a...

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PMID: 16322245
DOI: 10.1158/0008-5472.can-05-2327

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