Article
The mojastin mutant Moj-DM induces apoptosis of the human melanoma SK-Mel-28, but not the mutant Moj-NN nor the non-mutated recombinant Moj-WN.
Toxicon : official journal of the International Society on Toxinology - 1 Sept 2010
Seoane Agustin I, Tran Victoria L, Sanchez Elda E, White Stephanie A, Choi Jason L, Gaytán Brandon, Chavez Natalie, Reyes Steven R, Ramos Carla J, Tran Luan H, Lucena Sara E, Sugarek Maria, Perez John C, Mandal Stephanie A, Ghorab Shervin, Rodriguez-Acosta Alexis, Fung Branden K, Soto Julio G
Abstract excerpt
In this study, three recombinant mojastin peptides (Moj-WN, Moj-NN, and Moj-DM) were produced and compared functionally. Recombinant Moj peptides were purified as GST-fusions. GST-Moj-WN and GST-Moj-NN inhibited ADP-induced platelet aggregation in platelet rich plasma. The GST-Moj-WN had an IC(50) of 160nM, while the GST-Moj-NN had an IC(50) of 493nM. The GST-Moj-DM did not inhibit platelet aggregation. All three...
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