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Regression of Human Breast Carcinoma in Nude Mice After Ad <i>sflt</i> Gene Therapy is Mediated by Tumor Vascular Endothelial Cell Apoptosis

2020-07-19

Abstract excerpt

Two vascular endothelial growth factor (VEGF) receptors, FLT-1 and KDR, are expressed preferentially in proliferating endothelium. There is increasing evidence that recombinant, soluble VEGF receptor domains interfering with VEGF signaling may inhibit in vivo neoangiogenesis, tumor growth and metastatic spread. We hypothesized that a soluble form of FLT-1 receptor (sFLT-1) could inhibit the growth of pre-establis...

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Literature Corpus work
db3127a1-28c0-50ca-9399-c5889e0fcf65
DOI
10.1101/2020.07.19.210856
Open publication

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Regression of Human Breast Carcinoma in Nude Mice After Ad <i>sflt</i> Gene Therapy is Mediated by Tumor Vascular Endothelial Cell ApoptosisDOI 10.1101/2020.07.19.210856
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