Article
Specific alpha v integrin receptors modulate K1735 murine melanoma cell behavior.
Biochemical and biophysical research communications - 5 Sept 2003
Yang Yongjian, Dang Dongmin, Atakilit Amha, Schmidt Brian, Regezi Joseph, Li Xiaowu, Eisele David, Ellis Duncan, Ramos Daniel M
Abstract excerpt
Expression of beta 3 integrins is increased in invasive melanoma. In this study we show that K1735 cell proliferation is enhanced by the expression of either beta 3 or a constitutively active Src. We investigated possible modulators of FN matrix assembly and found that matrix metalloproteinase 2 (MMP2) was activated by alpha v beta 3. alpha v beta 3 integrin was localized to focal contacts whereas alpha v beta 5...
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