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Article

Adenovirus-mediated expression of mutated forkhead human transcription like-1 suppresses tumor growth in a mouse melanoma xenograft model.

Cancer biology & therapy - 1 Oct 2012

Gomez-Gutierrez Jorge G, Egger Michael E, Hao Hongying, Zhou Heshan Sam, McMasters Kelly M

Abstract excerpt

Melanoma is generally resistant to chemotherapy, which may be related to defects in death receptor signaling and to defects in induction of apoptosis. Forkhead family transcription factors induce the expression of death receptor ligands such as Fas ligand (Fas-L) resulting in apoptosis. We therefore investigated whether a triple mutant form of forkhead transcription factor FKHRL1 (FKHRL1/TM) can enhance Fas-L...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22892845
DOI: 10.4161/cbt.21349
PMCID: PMC3469477

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