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Article

Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1.

The Journal of biological chemistry - 22 Oct 2004

Lee Joon No, Ye Jin

Abstract excerpt

Insig-1 and Insig-2 are closely related proteins of the endoplasmic reticulum (ER) that block proteolytic activation of sterol regulatory element-binding proteins (SREBPs), membrane-bound transcription factors that activate synthesis of cholesterol and fatty acids in animal cells. When cellular cholesterol levels are high, Insig proteins bind to SREBP cleavage-activating protein, retaining it in the ER and...

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Identifiers

PMID: 15304479
DOI: 10.1074/jbc.M408235200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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