Article
Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation.
Molecular biology of the cell - 1 Jul 2009
Leichner Gil S, Avner Rachel, Harats Dror, Roitelman Joseph
Abstract excerpt
The endoplasmic reticulum (ER) glycoprotein HMG-CoA reductase (HMGR) catalyzes the rate-limiting step in sterols biosynthesis. Mammalian HMGR is ubiquitinated and degraded by the proteasome when sterols accumulate in cells, representing the best example for metabolically controlled ER-associated degradation (ERAD). This regulated degradation involves the short-lived ER protein Insig-1. Here, we investigated the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.