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Article

Small-molecule dimerization inhibitors of wild-type and mutant HIV protease: a focused library approach.

Journal of the American Chemical Society - 18 Aug 2004

Shultz Michael D, Ham Young-Wan, Lee Song-Gil, Davis David A, Brown Cara, Chmielewski Jean

Abstract excerpt

We demonstrate that a focused library based on truncated, cross-linked interfacial peptides of HIV-1 protease produces effective dimerization inhibitors of the enzyme. By combining individual changes of the library into a single compound, we obtained a significantly more potent agent and found that an additive increase in inhibitor efficacy was obtained. The good activity of library members against an active-site...

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Identifiers

PMID: 15303839
DOI: 10.1021/ja048139n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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