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Article

A picomolar inhibitor of resistant strains of human immunodeficiency virus protease identified by a combinatorial approach.

Archives of biochemistry and biophysics - 1 Oct 2000

Rinnová M, Hradilek M, Barinka C, Weber J, Soucek M, Vondrásek J, Klimkait T, Konvalinka J

Abstract excerpt

In order to identify inhibitors of various drug-resistant forms of the human immunodeficiency virus protease (HIV PR), we have designed and synthesized pseudopeptide libraries with a general structure Z-mimetic-Aa1-Aa2-NH2. Five different chemistries for peptide bond replacement have been employed and the resulting five individual sublibraries tested with the HIV PR and its drug-resistant mutants. Each mutant...

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Source

Identifiers

PMID: 11051093
DOI: 10.1006/abbi.2000.2017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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