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Article

Detailed mechanistic insights into HIV-1 sensitivity to three generations of fusion inhibitors.

The Journal of biological chemistry - 25 Sept 2009

Eggink Dirk, Langedijk Johannes P M, Bonvin Alexandre M J J, Deng Yiqun, Lu Min, Berkhout Ben, Sanders Rogier W

Abstract excerpt

Peptides based on the second heptad repeat (HR2) of viral class I fusion proteins are effective inhibitors of virus entry. One such fusion inhibitor has been approved for treatment of human immunodeficiency virus-1 (T20, enfuvirtide). Resistance to T20 usually maps to the peptide binding site in HR1. To better understand fusion inhibitor potency and resistance, we combined virological, computational, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19617355
DOI: 10.1074/jbc.M109.004416
PMCID: PMC2785381

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