Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neuronal accumulation of abnormal prion protein in sheep carrying a scrapie-resistant genotype (PrPARR/ARR).

The Journal of general virology - 1 Sept 2004

Buschmann Anne, Lühken Gesine, Schultz Julia, Erhardt G, Groschup Martin H

Abstract excerpt

The susceptibility of sheep to scrapie infection is influenced by prion gene alleles, which are modulated by polymorphic variations corresponding to amino acid positions 136, 154 and 173 of the prion protein (PrP). As no unquestioned report of a diseased sheep carrying homozygous alleles encoding alanine, arginine and arginine (PrPARR) at these sites has been published to date, sheep of this genotype are believed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Arginine
Share to Germany

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoblotting

Share to Neurons

Share to PrPSc Proteins

Share to Scrapie

Source

Identifiers

PMID: 15302966
DOI: 10.1099/vir.0.79997-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuronal accumulation of abnormal prion protein in sheep carrying a scrapie-resistant genotype (PrPARR/ARR).PMID 15302966Read ↗

Classic scrapie in sheep with the ARR/ARR prion genotype in Germany and France.Semantic proximity Read ↗

Incidence of infection in Prnp ARR/ARR sheep following experimental inoculation with or natural exposure to classical scrapie.Semantic proximity Read ↗

A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes.Semantic proximity Read ↗

Influence of polymorphisms in the prion protein gene on the pathogenesis and neuropathological phenotype of sheep scrapie after oral infection.Semantic proximity Read ↗

PrP genotyping of Austrian sheep breeds.Semantic proximity Read ↗

A case of scrapie in a sheep carrying the lysine-171 allele of the prion protein gene.Semantic proximity Read ↗

Abnormal prion protein in genetically resistant sheep from a scrapie-infected flock.Semantic proximity Read ↗

Proteinase K-resistant material in ARR/VRQ sheep brain affected with classical scrapie is composed mainly of VRQ prion protein.Semantic proximity Read ↗

PrP genotypes of atypical scrapie cases in Great Britain.Semantic proximity Read ↗

Prion protein gene polymorphisms in healthy and scrapie-affected Spanish sheep.Semantic proximity Read ↗

Frequency of genotypes in the PrP prion protein gene locus in the Polish sheep population.Semantic proximity Read ↗

The PrP(C) C1 fragment derived from the ovine A136R154R171PRNP allele is highly abundant in sheep brain and inhibits fibrillisation of full-length PrP(C) protein in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.