Prion protein gene polymorphisms in healthy and scrapie-affected Spanish sheep.

doi:10.1099/vir.0.80047-0

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Article

Prion protein gene polymorphisms in healthy and scrapie-affected Spanish sheep.

The Journal of general virology - 1 Jul 2004

Acín Cristina, Martín-Burriel Inmaculada, Goldmann Wilfred, Lyahyai Jaber, Monzón Marta, Bolea Rosa, Smith Allister, Rodellar Clementina, Badiola Juan José, Zaragoza Pilar

Abstract excerpt

The Rasa Aragonesa sheep is the second most important Spanish breed after the Merino breed. Reported here is the prion protein (PrP) haplotype frequency distribution for scrapie-related codons (136, 154 and 171) and a sequencing study of the complete PrP gene open reading frame for this breed and six other closely related breeds. The study includes four scrapie-affected sheep flocks belonging to Rasa Aragonesa...

Topics

Animals
Base Sequence
Codon
DNA Primers
Genotype
Haplotypes
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Prions
Reference Values
Sheep
Sheep Diseases
Spain

Source

Open in PubMed

Identifiers

PMID: 15218196
DOI: 10.1099/vir.0.80047-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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