Article
Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.
Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 2004
Ashur-Fabian Osnat, Avivi Aaron, Trakhtenbrot Luba, Adamsky Konstantin, Cohen Meytal, Kajakaro Gadi, Joel Alma, Amariglio Ninette, Nevo Eviatar, Rechavi Gideon
Abstract excerpt
The tumor suppressor gene p53 controls cellular response to a variety of stress conditions, including DNA damage and hypoxia, leading to growth arrest and/or apoptosis. Inactivation of p53, found in 40-50% of human cancers, confers selective advantage under hypoxic microenvironment during tumor progression. The mole rat, Spalax, spends its entire life cycle underground at decidedly lower oxygen tensions than any...
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