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Article

Transcription pattern of p53-targeted DNA repair genes in the hypoxia-tolerant subterranean mole rat Spalax.

Journal of molecular biology - 12 Apr 2013

Shams Imad, Malik Assaf, Manov Irena, Joel Alma, Band Mark, Avivi Aaron

Abstract excerpt

The tumor suppressor gene p53 induces growth arrest and/or apoptosis in response to DNA damage/hypoxia. Inactivation of p53 confers a selective advantage to tumor cells under a hypoxic microenvironment during tumor progression. The subterranean blind mole rat, Spalax, spends its life underground at low-oxygen tensions, hence developing a wide range of respiratory/molecular adaptations to hypoxic stress, including...

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Adaptation, Physiological
Adaptor Proteins, Signal Transducing
Cell Cycle Checkpoints
Cell Cycle Proteins
DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MutS Homolog 2 Protein

Ribonucleotide Reductases

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PMID: 23318952
DOI: 10.1016/j.jmb.2013.01.007

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