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Hypoxia‐induced <i>BNIP3</i> expression and mitophagy: <i>in vivo</i> comparison of the rat and the hypoxia‐tolerant mole rat, <i>Spalax ehrenbergi</i>

2 Mar 2009

Abstract excerpt

The blind subterranean mole rat of the Spalax ehrenbergi superspecies is an excellent animal model for hypoxic tolerance. Unique physiological, functional, and gene structure changes allow Spalax species to survive lower oxygen levels than most terrestrial animals. BNIP3, an HIF-1 dependent hypoxia-response gene, has a proapoptotic function; however, expression is suppressed in many types of cancers. Under...

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PMID: 19255257
DOI: 10.1096/fj.08-122978

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