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Adaptation of the <i>Spalax galili</i> transcriptome to life under hypoxia may hold a key to a complex phenotype including longevity and cancer resistance

2023-08-03

Abstract excerpt

The muroid rodent Nannospalax galili (syn. Spalax ) is adapted to life in underground burrows and tolerates acute exposure to severe hypoxia. Adaptation to hypoxia is correlated with delayed onset of ageing and resistance against tumour formation. Spalax becomes five to seven times older than its relatives, the mouse and rat, without displaying signs of ageing or developing ageing-related disorders like cancer....

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Literature Corpus work
ff93e247-98c7-5efc-94be-9e89ff72b16a
DOI
10.1101/2023.08.01.551427
Open publication

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