Article
p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen.
The Journal of cell biology - 2 Nov 2020
Valente Liz J, Tarangelo Amy, Li Albert Mao, Naciri Marwan, Raj Nitin, Boutelle Anthony M, Li Yang, Mello Stephano Spano, Bieging-Rolett Kathryn, DeBerardinis Ralph J, Ye Jiangbin, Dixon Scott J, Attardi Laura D
Abstract excerpt
The mechanisms by which TP53, the most frequently mutated gene in human cancer, suppresses tumorigenesis remain unclear. p53 modulates various cellular processes, such as apoptosis and proliferation, which has led to distinct cellular mechanisms being proposed for p53-mediated tumor suppression in different contexts. Here, we asked whether during tumor suppression p53 might instead regulate a wide range of...
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