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PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth

20 Sept 2022

Abstract excerpt

Egg activation in mammals is triggered by oscillations in egg intracellular calcium (Ca2+) level. Ca2+ oscillation patterns can be modified in vitro by changing the ionic composition of culture media or in vivo by conditions affecting mitochondrial function, such as obesity and inflammation. In mice, disruption of Ca2+ oscillations in vitro impacts embryo development and offspring growth. Here we tested the...

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PMID: 36130203
DOI: 10.1093/biolre/ioac180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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