Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2012

de Lau Lonneke M L, Verbaan Dagmar, Marinus Johan, Heutink Peter, van Hilten Jacobus J

Abstract excerpt

BACKGROUND: The A-allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability. METHODS: We studied 219 patients with PD who were free of dyskinesias at baseline and underwent thorough annual examinations. RESULTS: The A-allele of the COMT Val158Met polymorphism was related to an increased risk of developing dyskinesias...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dyskinesia, Drug-Induced

Share to Dyskinesias

Share to Methionine

Share to Parkinson Disease

Share to Proportional Hazards Models

Share to Valine

Source

Identifiers

PMID: 22083803
DOI: 10.1002/mds.23805

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease.PMID 22083803Read ↗

Association of catechol-o-methyltransferase polymorphism (Val108/158Met) with Parkinson's disease: a meta-analysis.Semantic proximity Read ↗

The COMT Val158Met polymorphism as an associated risk factor for Parkinson's disease in Asian rather than Caucasian populations.Semantic proximity Read ↗

Val158Met polymorphism of COMT gene and Parkinson's disease risk in Asians.Semantic proximity Read ↗

Association between catechol-O-methyltransferase gene polymorphisms and wearing-off and dyskinesia in Parkinson's disease.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism influences prefrontal executive function in early Parkinson's disease.Semantic proximity Read ↗

Association of Catechol-O-Methyltransferase Gene rs4680 Polymorphism and Levodopa Induced Dyskinesia in Parkinson's Disease: A Meta-Analysis and Systematic Review.Semantic proximity Read ↗

Catechol-O-methyltransferase Val158Met polymorphism: modulation of wearing-off susceptibility in a Chinese cohort of Parkinson's disease.Semantic proximity Read ↗

Association of COMT Val158Met polymorphism with wearing-off susceptibility in Parkinson's disease.Semantic proximity Read ↗

The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complicationsSemantic proximity Read ↗

COMT gene and risk for Parkinson's disease: a systematic review and meta-analysis.Semantic proximity Read ↗

Catechol-O-methyltransferase and Parkinson's disease.Semantic proximity Read ↗

Roles of functional catechol-O-methyltransferase genotypes in Chinese patients with Parkinson’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.