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Article

The BDNF Val66Met polymorphism has a gender specific influence on planning ability in Parkinson's disease.

Journal of neurology - 1 Jul 2005

Foltynie Thomas, Lewis Simon G J, Goldberg Terry E, Blackwell Andrew D, Kolachana Bhaskar S, Weinberger Daniel R, Robbins Trevor W, Barker Roger A

Abstract excerpt

Parkinson's disease (PD) patients show a range of cognitive deficits,which may relate to abnormalities in dopaminergic transmission in fronto-striatal circuitry. In this study, we have investigated the impact of brainderived neurotrophic factor (BDNF) val66met polymorphisms on performance of the Tower of London (TOL) test of planning by PD patients. This polymorphism significantly influences BDNF secretion in the...

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Source

Identifiers

PMID: 15772739
DOI: 10.1007/s00415-005-0756-5

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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