Oral contraceptives and breast cancer risk in the international BRCA1/2 carrier cohort study: a report from EMBRACE, GENEPSO, GEO-HEBON, and the IBCCS Collaborating Group.

doi:10.1200/JCO.2007.11.1179

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Oral contraceptives and breast cancer risk in the international BRCA1/2 carrier cohort study: a report from EMBRACE, GENEPSO, GEO-HEBON, and the IBCCS Collaborating Group.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Sept 2007

Brohet Richard M, Goldgar David E, Easton Douglas F, Antoniou Antonis C, Andrieu Nadine, Chang-Claude Jenny, Peock Susan, Eeles Rosalind A, Cook Margaret, Chu Carol, Noguès Catherine, Lasset Christine, Berthet Pascaline, Meijers-Heijboer Hanne, Gerdes Anne-Marie, Olsson Håkan, Caldes Trinidad, van Leeuwen Flora E, Rookus Matti A

Abstract excerpt

PURPOSE Earlier studies have shown that endogenous gonadal hormones play an important role in the etiology of breast cancer among BRCA1/2 mutation carriers. So far, little is known about the safety of exogenous hormonal use in mutation carriers. In this study, we examined the association between oral contraceptive use and risk of breast cancer among BRCA1/2 carriers. PATIENTS AND METHODS In the International...

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Identifiers

PMID: 17635951
DOI: 10.1200/JCO.2007.11.1179

Genes

BRCA1
BRCA2

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