Article
HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection.
Science (New York, N.Y.) - 6 Aug 2004
Khakoo Salim I, Thio Chloe L, Martin Maureen P, Brooks Collin R, Gao Xiaojiang, Astemborski Jacquie, Cheng Jie, Goedert James J, Vlahov David, Hilgartner Margaret, Cox Steven, Little Ann-Margeret, Alexander Graeme J, Cramp Matthew E, O'Brien Stephen J, Rosenberg William M C, Thomas David L, Carrington Mary
Abstract excerpt
Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group 1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This...
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