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Article

KIR2DL3⁺NKG2A⁻ natural killer cells are associated with protection from productive hepatitis C virus infection in people who inject drugs.

Journal of hepatology - 1 Sept 2014

Thoens Christine, Berger Christoph, Trippler Martin, Siemann Holger, Lutterbeck Melanie, Broering Ruth, Schlaak Jörg, Heinemann Falko M, Heinold Andreas, Nattermann Jacob, Scherbaum Norbert, Alter Galit, Timm Joerg

Abstract excerpt

BACKGROUND & AIMS: Despite continuous high-risk behavior, a subgroup among people who inject drugs (PWID) remains seronegative for hepatitis C virus (HCV) suggesting that a state of "natural resistance" to HCV Infection may exist. Homozygosity for KIR2DL3 and its ligand HLA-C1 group alleles has been associated with control of HCV infection, however, the mechanism mediating this protective effect remained unclear....

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Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA-E Antigens

Share to Killer Cells, Natural

Share to NK Cell Lectin-Like Receptor Subfamily C

Share to Receptors, KIR2DL3

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Source

Identifiers

PMID: 24780303
DOI: 10.1016/j.jhep.2014.04.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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