Article
Interaction of NK inhibitory receptor genes with HLA-C and MHC class II alleles in Hepatitis C virus infection outcome.
Molecular immunology - 1 May 2008
Romero Viviana, Azocar Jose, Zúñiga Joaquin, Clavijo Olga P, Terreros Daniel, Gu Xiangjun, Husain Zaheed, Chung Raymond T, Amos Christopher, Yunis Edmond J
Abstract excerpt
Natural killer cells are important in innate defense against viral infections. The interplay between stimulatory and inhibitory natural killer cell receptors and their corresponding human leukocyte antigen ligands are known to influence the outcome of acute Hepatitis C virus infection. Frequencies of NK receptor genes (8 inhibitory, 6 activating and 2 pseudogenes) and HLA class II alleles (DRB1, DQB1) were...
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