Article
Interferon-γ Inhibits STAT6 Signal Transduction and Gene Expression in Human Airway Epithelial Cells
5 Aug 2004
Abstract excerpt
The activating and inhibitory cytokine signals that act upon epithelial cells in the human lung are critically important for controlling the production of inflammatory mediators from those cells in the context of allergic disease. The cytokines interleukin (IL)-4 and IL-13, derived from T helper (Th)-2 cells and other cell types, are potent inducers of epithelial cell expression of a host of inflammatory...
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