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Article

Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons.

The Journal of allergy and clinical immunology - 1 Jul 2015

Gielen Vera, Sykes Annemarie, Zhu Jie, Chan Brian, Macintyre Jonathan, Regamey Nicolas, Kieninger Elisabeth, Gupta Atul, Shoemark Amelia, Bossley Cara, Davies Jane, Saglani Sejal, Walker Patrick, Nicholson Sandra E, Dalpke Alexander H, Kon Onn-Min, Bush Andrew, Johnston Sebastian L, Edwards Michael R

Abstract excerpt

BACKGROUND: Rhinovirus infections are the dominant cause of asthma exacerbations, and deficient virus induction of IFN-α/β/λ in asthmatic patients is important in asthma exacerbation pathogenesis. Mechanisms causing this interferon deficiency in asthmatic patients are unknown. OBJECTIVE: We sought to investigate the expression of suppressor of cytokine signaling (SOCS) 1 in tissues from asthmatic patients and its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25630941
DOI: 10.1016/j.jaci.2014.11.039
PMCID: PMC4541718

Genes

SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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