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Cutting Edge: Type I IFN Reverses Human Th2 Commitment and Stability by Suppressing GATA3

17 Jun 2010

Abstract excerpt

T helper 2 cells regulate inflammatory responses to helminth infections while also mediating pathological processes of asthma and allergy. IL-4 promotes Th2 development by inducing the expression of the GATA3 transcription factor, and the Th2 phenotype is stabilized by a GATA3-dependent autoregulatory loop. In this study, we found that type I IFN (IFN-alpha/beta) blocked human Th2 development and inhibited...

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PMID: 20554961
DOI: 10.4049/jimmunol.1000469

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