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Article

Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma

1 May 1999

Abstract excerpt

Cytokine effects on immunity and inflammation often depend on the transcription factors termed signal transducers and activators of transcription (STATs), so STAT signaling pathways are candidates for influencing inflammatory disease. We reasoned that selective IFN responsiveness of the first STAT family member (Stat1) and Stat1-dependent immune-response genes such as intercellular adhesion molecule-1 (ICAM-1),...

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PMID: 10225979
DOI: 10.1172/jci6130

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