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Article

Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons

1 Mar 1999

Abstract excerpt

The Th2-type cytokines, interleukin-4 (IL-4) and interleukin-13 (IL-13), induce expression of a distinct subset of genes in human monocytes, including FcepsilonRIIb (CD23), 15-lipoxygenase, IL-1 receptor antagonist (IL-1ra), and type I and type II IL-1 receptors (IL-1R). Type I interferons (IFN-alpha and IFN-beta) and type II interferon (IFN-gamma) inhibit induction of these genes by IL-4 and IL-13. However, the...

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PMID: 10080532
DOI: 10.1002/jlb.65.3.307

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