Article

Repression of IL-4-Induced Gene Expression by IFN-γ Requires Stat1 Activation

1999-04-01

Abstract excerpt

Abstract IFN-γ antagonizes many physiological responses mediated by IL-4, including the inhibition of IL-4-induced IgE production. This event is largely mediated at the level of transcription. We observed that the IL-4 response element of the germline epsilon promoter is sufficient to confer IFN-γ-mediated repression onto a reporter construct. The inhibitory effects were observed in both lymphoid and nonlymphoid c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3c4829c5-12e9-53ea-9656-0d20619a75d8
DOI: 10.4049/jimmunol.162.7.4053

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Repression of IL-4-Induced Gene Expression by IFN-γ Requires Stat1 ActivationDOI 10.4049/jimmunol.162.7.4053Read

Stat1-independent regulation of gene expression in response to IFN-γSemantic proximity Read

Severe impairment of IFN-γ and IFN-α responses in cells of a patient with a novel STAT1 splicing mutation.Semantic proximity Read

Interferon-γ Inhibits STAT6 Signal Transduction and Gene Expression in Human Airway Epithelial CellsSemantic proximity Read

The IFN-γ–Dependent Suppressor of Cytokine Signaling 1 Promoter Activity Is Positively Regulated by IFN Regulatory Factor-1 and Sp1 but Repressed by Growth Factor Independence-1b and Krüppel-Like Factor-4, and It Is Dysregulated in Psoriatic KeratinocytesSemantic proximity Read

IFN-α Induces the Human IL-10 Gene by Recruiting Both IFN Regulatory Factor 1 and Stat3Semantic proximity Read

Signaling through a mutant IFN-gamma receptor.Semantic proximity Read

IL-4 and IL-13 Induce SOCS-1 Gene Expression in A549 Cells by Three Functional STAT6-Binding Motifs Located Upstream of the Transcription Initiation SiteSemantic proximity Read

Unphosphorylated STAT1 Promotes Sarcoma Development through Repressing Expression of Fas and Bad and Conferring Apoptotic ResistanceSemantic proximity Read

Experimental regulation of STAT gene expression reveals an involvement of STAT5 in interleukin-4-driven cell proliferation.Semantic proximity Read

The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors.Semantic proximity Read

TGF-β1 inhibition of IFN-γ-induced signaling and Th1 gene expression in CD4+ T cells is Smad3 independent but MAP kinase dependentSemantic proximity Read

Recruitment of Stat4 to the Human Interferon-α/β Receptor Requires Activated Stat2Semantic proximity Read