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Article

Aluminum hydroxide adjuvant induces macrophage differentiation towards a specialized antigen-presenting cell type.

Vaccine - 13 Aug 2004

Rimaniol Anne-Cécile, Gras Gabriel, Verdier François, Capel Francis, Grigoriev Vladimir B, Porcheray Fabrice, Sauzeat Elisabeth, Fournier Jean-Guy, Clayette Pascal, Siegrist Claire-Anne, Dormont Dominique

Abstract excerpt

Aluminum hydroxide (AlOOH) has been used for many years as a vaccine adjuvant, but little is known about its mechanism of action. We investigated in this study the in vitro effect of aluminum hydroxide adjuvant on isolated macrophages. We showed that AlOOH-stimulated macrophages contain large and persistent intracellular crystalline inclusions, a characteristic property of muscle infiltrated macrophages described...

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Identifiers

PMID: 15297065
DOI: 10.1016/j.vaccine.2004.01.061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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