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Article

Adjuvant conditioning enhances neutrophil function while inducing a suppressive peritoneal macrophage phenotype.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2025

Boccia Thais, Fattori Victor, Veloso Da Silva Matheus Deroco, Asquith Nathan L, Pan Weikang, Rogers Michael S, Zanoni Ivan, Cuenca Alex G

Abstract excerpt

Adjuvants are widely used to boost the immune response during vaccination protocols. Our group has previously reported that repeated intraperitoneal administration of alum in mice, known as adjuvant conditioning (AC), creates an immunosuppressive environment that delays allogeneic graft rejection through NLRP3-dependent MDSC expansion. However, little is known about the effects of AC on the reprogramming of...

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Share to Adjuvants, Immunologic
Share to Immunity, Innate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammasomes

Share to Macrophages, Peritoneal

Share to Mice, Inbred C57BL

Share to Mice, Knockout

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Share to NLR Family, Pyrin Domain-Containing 3 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 40897376
DOI: 10.1093/jimmun/vkaf206
PMCID: PMC12726067

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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