Article
Harvesting murine alveolar macrophages and evaluating cellular activation induced by polyanhydride nanoparticles.
Journal of visualized experiments : JoVE - 8 Jun 2012
Chavez-Santoscoy Ana V, Huntimer Lucas M, Ramer-Tait Amanda E, Wannemuehler Michael, Narasimhan Balaji
Abstract excerpt
Biodegradable nanoparticles have emerged as a versatile platform for the design and implementation of new intranasal vaccines against respiratory infectious diseases. Specifically, polyanhydride nanoparticles composed of the aliphatic sebacic acid (SA), the aromatic 1,6-bis(p-carboxyphenoxy)hexane (CPH), or the amphiphilic 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG) display unique bulk and surface erosion...
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