Generalised Modules for Membrane Antigens (GMMA) Do Not Elicit Concerning Local Reactogenicity after Intramuscular Injection in Absence of Aluminum Salt Adjuvant

Abstract excerpt

Generalised Modules for Membrane Antigens (GMMA) are outer membrane vesicles derived from Gram-negative bacteria that can be used to design affordable subunit vaccines. GMMA are highly immunogenic and capable to induce an optimal antigen-specific humoral immune response both in animals and humans. Despite their potent immunogenicity, GMMA are usually formulated with aluminum salts (Alum) to reduce their potential...

Topics

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• Antibodies, Bacterial
• Bacterial Infections and Vaccines
• Bacteriophages and microbial interactions
• Clostridium difficile and Clostridium perfringens research
• Escherichia coli research studies
• Mutation
• Pneumonia and Respiratory Infections
• Viral gastroenteritis research and epidemiology

Identifiers and source

Literature Corpus work

466b8996-790c-574f-8b4e-937fe66a328e

DOI

10.20944/preprints202408.0730.v1