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Article

A simple molecular complex mediates widespread BMP-induced repression during Drosophila development.

Developmental cell - 1 Aug 2004

Pyrowolakis George, Hartmann Britta, Müller Bruno, Basler Konrad, Affolter Markus

Abstract excerpt

The spatial and temporal control of gene expression during the development of multicellular organisms is regulated to a large degree by cell-cell signaling. We have uncovered a simple mechanism through which Dpp, a TGFbeta/BMP superfamily member in Drosophila, represses many key developmental genes in different tissues. A short DNA sequence, a Dpp-dependent silencer element, is sufficient to confer repression of...

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PMID: 15296719
DOI: 10.1016/j.devcel.2004.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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