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Article

MADR1, a MAD-related protein that functions in BMP2 signaling pathways.

Cell - 17 May 1996

Hoodless P A, Haerry T, Abdollah S, Stapleton M, O'Connor M B, Attisano L, Wrana J L

Abstract excerpt

Components of the signaling pathways that lie downstream of Ser/Thr kinase receptors and are required for signaling by the TGF beta superfamily have been poorly defined. The Drosophila gene Mothers against dpp (MAD) and the C. elegans sma genes are implicated in these signaling pathways. We show that MAD functions downstream of DPP receptors and is required for receptor signaling. Phosphorylation of MADR1, a...

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Identifiers

PMID: 8653785
DOI: 10.1016/s0092-8674(00)81250-7

Genes

BMP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MADR1, a MAD-related protein that functions in BMP2 signaling pathways.PMID 8653785Read ↗

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Smads are the central component in transforming growth factor-beta signaling.Semantic proximity Read ↗

The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans.Semantic proximity Read ↗

Selective Disruption of Synaptic BMP Signaling by a Smad Mutation Adjacent to the Highly Conserved H2 Helix.Semantic proximity Read ↗

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.Semantic proximity Read ↗

Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling.Semantic proximity Read ↗

Dpp-responsive silencers are bound by a trimeric Mad-Medea complex.Semantic proximity Read ↗

Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.Semantic proximity Read ↗

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