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The Dpp/TGFβ-Dependent Corepressor Schnurri Protects Epithelial Cells from JNK-Induced Apoptosis in Drosophila Embryos

1 Oct 2014

Abstract excerpt

Jun N-terminal kinase (JNK) often mediates apoptosis in response to cellular stress. However, during normal development, JNK signaling controls a variety of live cell behaviors, such as during dorsal closure in Drosophila embryos. During this process, the latent proapoptotic activity of JNK becomes apparent following Dpp signaling suppression, which leads to JNK-dependent transcriptional activation of the...

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PMID: 25307481
DOI: 10.1016/j.devcel.2014.08.015

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Research trail→

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The Dpp/TGFβ-Dependent Corepressor Schnurri Protects Epithelial Cells from JNK-Induced Apoptosis in Drosophila EmbryosPMID 25307481Read ↗

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Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.Semantic proximity Read ↗

Short-term activation of the Jun N-terminal kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis.Semantic proximity Read ↗

Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper.Semantic proximity Read ↗

Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement.Semantic proximity Read ↗

Snail modulates JNK-mediated cell death in Drosophila.Semantic proximity Read ↗

Dpp signalling orchestrates dorsal closure by regulating cell shape changes both in the amnioserosa and in the epidermis.Semantic proximity Read ↗

Ras promotes cell survival in Drosophila by downregulating hid expression.Semantic proximity Read ↗

The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP family.Semantic proximity Read ↗

Expression of the apoptosis gene reaper in homeotic, segmentation and other mutants in Drosophila.Semantic proximity Read ↗

Extrusion of cells with inappropriate Dpp signaling from Drosophila wing disc epithelia.Semantic proximity Read ↗

Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1.Semantic proximity Read ↗

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