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Article

A targeted adenovirus vector displaying a human fibronectin type III domain-based monobody in a fiber protein.

Biomaterials - 1 May 2013

Matsui Hayato, Sakurai Fuminori, Katayama Kazufumi, Abe Yasuhiro, Machitani Mitsuhiro, Kurachi Shinnosuke, Tachibana Masashi, Mizuguchi Hiroyuki

Abstract excerpt

A major drawback of adenovirus (Ad) vectors is their nonspecific transduction into various types of cells or tissue after in vivo application, which might lead to unexpected toxicity and tissue damage. To overcome this problem, we developed a fiber-mutant Ad vector displaying a monobody specific for epidermal growth factor receptor (EGFR) or vascular endothelial growth factor receptor 2 (VEGFR2) in the C-terminus...

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Source

Identifiers

PMID: 23473963
DOI: 10.1016/j.biomaterials.2013.02.046

Genes

EGFR
SPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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