Article
Complete complement components C4A and C4B deficiencies in human kidney diseases and systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2004
Yang Yan, Lhotta Karl, Chung Erwin K, Eder Paula, Neumair Friedrich, Yu C Yung
Abstract excerpt
Although a heterozygous deficiency of either complement component C4A or C4B is common, and each has a frequency of approximately 20% in a Caucasian population, complete deficiencies of both C4A and C4B proteins are extremely rare. In this paper the clinical courses for seven complete C4 deficiency patients are described in detail, and the molecular defects for complete C4 deficiencies are elucidated. Three...
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