Article
Deficiencies of human complement component C4A and C4B and heterozygosity in length variants of RP-C4-CYP21-TNX (RCCX) modules in caucasians. The load of RCCX genetic diversity on major histocompatibility complex-associated disease.
The Journal of experimental medicine - 19 Jun 2000
Blanchong C A, Zhou B, Rupert K L, Chung E K, Jones K N, Sotos J F, Zipf W B, Rennebohm R M, Yung Yu C
Abstract excerpt
The complement component C4 genes located in the major histocompatibility complex (MHC) class III region exhibit an unusually complex pattern of variations in gene number, gene size, and nucleotide polymorphism. Duplication or deletion of a C4 gene always concurs with its neighboring genes serine...
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