Article
The molecular basis of complete complement C4A and C4B deficiencies in a systemic lupus erythematosus patient with homozygous C4A and C4B mutant genes.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2002
Rupert Kristi L, Moulds Joann M, Yang Yan, Arnett Frank C, Warren Robert W, Reveille John D, Myones Barry L, Blanchong Carol A, Yu C Yung
Abstract excerpt
The disease course of a complete C4-deficient patient in the U.S. was followed for 18 years. The patient experienced multiple episodes of infection, and he was diagnosed with systemic lupus erythematosus at age 9 years. The disease progressed to WHO class III mild lupus nephritis and to fatal CNS vasculitis at age 23 years. Immunochemical experiments showed that the patient and his sibling had complete absence of...
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