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Article

The intricate role of complement component C4 in human systemic lupus erythematosus.

Current directions in autoimmunity - 1 Jan 2004

Yang Yan, Chung Erwin K, Zhou Bi, Lhotta Karl, Hebert Lee A, Birmingham Daniel J, Rovin Brad H, Yu C Yung

Abstract excerpt

It was observed about 50 years ago that low serum complement activity or low protein concentrations of complement C4 concurred with disease activities of systemic lupus erythematosus (SLE). Complete deficiencies of complement components C4A and C4B, albeit rare in human populations, are among the strongest genetic risk factors for SLE or lupus-like disease, across HLA haplotypes and racial backgrounds. However,...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Complement C4
Gene Deletion
Genetic Variation
Humans
Immune Complex Diseases
Lupus Erythematosus, Systemic
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14719377
DOI: 10.1159/000075689

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