Article
Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication.
The Journal of biological chemistry - 18 Mar 1994
Shen L, Wu L C, Sanlioglu S, Chen R, Mendoza A R, Dangel A W, Carroll M C, Zipf W B, Yu C Y
Abstract excerpt
The correlation of many HLA-associated autoimmune and genetic diseases with the polymorphic complement C4 genes may be attributed to the presence of disease susceptibility genes in the close proximity of C4. We have cloned and characterized a pair of partially duplicated genes, RP1 and RP2, located 611 base pairs upstream of the human C4A and C4B genes, respectively. The putative RP protein, consisting of 364...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.