Article
Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication.
The Journal of biological chemistry - 18 Mar 1994
Shen L, Wu L C, Sanlioglu S, Chen R, Mendoza A R, Dangel A W, Carroll M C, Zipf W B, Yu C Y
Abstract excerpt
The correlation of many HLA-associated autoimmune and genetic diseases with the polymorphic complement C4 genes may be attributed to the presence of disease susceptibility genes in the close proximity of C4. We have cloned and characterized a pair of partially duplicated genes, RP1 and RP2, locat...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Cloning, Molecular
- Colonic Neoplasms
- Complement C4a
- Complement C4b
- DNA Primers
- Exons
- HLA Antigens
- Humans
- Introns