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Article

Real-time allele-specific amplification for sensitive detection of the BRAF mutation V600E.

Molecular and cellular probes - 1 Oct 2004

Jarry Anne, Masson Damien, Cassagnau Elisabeth, Parois Sigrid, Laboisse Christian, Denis Marc G

Abstract excerpt

BRAF is a cytoplasmic serine/threonine kinase in the MAPK pathway that transduces signals from RAS family members to MEK1/2. Mutations in the BRAF gene have been described in the majority of cutaneous melanomas, papillary thyroid carcinoma and to a lesser extent in other cancers. The predominant mutation reported is a single transversion in exon 15 (T1799A). We designed a real-time allele-specific PCR to detect...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15294323
DOI: 10.1016/j.mcp.2004.05.004

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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