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Article

Detection of mutant BRAF alleles in the plasma of patients with metastatic melanoma.

The Journal of molecular diagnostics : JMD - 1 Apr 2007

Yancovitz Molly, Yoon Joanne, Mikhail Maryann, Gai Weiming, Shapiro Richard L, Berman Russell S, Pavlick Anna C, Chapman Paul B, Osman Iman, Polsky David

Abstract excerpt

Mutations in the BRAF oncogene at amino acid 600 have been reported in 40 to 70% of human metastatic melanoma tissues, and the critical role of BRAF in the biology of melanoma has been established. Sampling the blood compartment to detect the mutational status of a solid tumor represents a highly innovative advance in cancer medicine, and such an approach could have advantages over tissue-based techniques. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17384209
DOI: 10.2353/jmoldx.2007.060135
PMCID: PMC1867452

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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