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Article

BRAF V600E mutation in metastatic colorectal cancer: Methods of detection and correlation with clinical and pathologic features.

Cancer biology & therapy - 2 Aug 2016

Roma Cristin, Rachiglio Anna Maria, Pasquale Raffaella, Fenizia Francesca, Iannaccone Alessia, Tatangelo Fabiana, Antinolfi Giuseppe, Parrella Paola, Graziano Paolo, Sabatino Lina, Colantuoni Vittorio, Botti Gerardo, Maiello Evaristo, Normanno Nicola

Abstract excerpt

The screening for BRAF V600E mutation is employed in clinical practice for its prognostic and potentially predictive role in patients with metastatic colorectal carcinoma (mCRC). Little information is available on the sensitivity and specificity of the testing methods to detect this mutation in CRC. By using serial dilution of BRAF mutant DNA with wild type DNA, we found that the sensitivity of allelic...

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Identifiers

PMID: 27261210
DOI: 10.1080/15384047.2016.1195048
PMCID: PMC5004691

Genes

BRAF
KRAS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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