Article
The structure of the tau haplotype in controls and in progressive supranuclear palsy.
Human molecular genetics - 15 Jun 2004
Pittman Alan M, Myers Amanda J, Duckworth Jaime, Bryden Leslie, Hanson Melissa, Abou-Sleiman Patrick, Wood Nicholas W, Hardy John, Lees Andrew, de Silva Rohan
Abstract excerpt
The group of neurodegenerative diseases collectively known as tauopathies are characterized by hallmark lesions consisting of fibrillar aggregates of the microtubule-associated protein, tau (MAPT). Mutations of the tau gene (MAPT) are the cause of frontotemporal dementia with parkinsonism linked to chromosome 17, giving tau a central role in the pathogenic process. The chromosomal region containing MAPT has been...
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