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Article

Motor and non-motor features in progressive supranuclear palsy: the impact of microtubule associated protein tau haplotypes among a Tunisian cohort.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Mar 2026

Abida Youssef, Sghaier Ikram, Souissi Amira, Gharbi Alya, Nasri Amina, Belkehia Oumeyma, Kacem Imen, Gargouri-Berrachid Amina, Gouider Riadh

Abstract excerpt

Progressive supranuclear palsy (PSP) is a neurodegenerative disorder that impacts movement and cognition,caused by abnormal tau protein accumulation in the brain. It involves tau aggregation with 4-repeat domains in various brain regions and cell types. PSP is associated with the tau gene (MAPT),which contains recurrent genomic inversion. Evaluate the distribution and clinical impact of MAPT haplotypes on both...

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PMID: 40810960
DOI: 10.1007/s00702-025-03004-z

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MAPT

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